Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction

Article Abstract:

The advances in the molecular mechanisms of protease inhibitor (PI)-induced endothelial dysfunction are described. The new discoveries have helped in understanding the molecular mechanisms of the interaction between HIV PIs and vascular cells and have also suggested some potential approaches to control HIV PI-associated cardiovascular complications.

Vascular endothelium, Clinical report

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Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries

Article Abstract:

A comparison between the effects of five commonly used protease inhibitors (PIs) on vasomotor function, endothelial nitric oxide synthase expression, and oxidative stress in porcine coronary arteries is presented. The results suggest that antioxidant therapy might have applications for controlling PI-associated cardiovascular complications.

Medical examination, Coronary arteries, Vasomotor conditioning, Cardiovascular conditioning

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Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression

Article Abstract:

The effects of the HIV protease inhibitor (PI) ritonavir on vasomotor function and endothelial nitric oxide synthase (eNOS) expression are determined. The study suggests that ritonavir may contribute to coronary artery disease formation in antiviral therapy for HIV-infected patients.

Health aspects, Usage, Ritonavir, Coronary heart disease, HIV patients, Dosage and administration

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