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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

Article Abstract:

The knock-in mice expressing the Noonan syndrome-associated mutation D61G was generated and characterized to address the relationship between Noonan syndrome and leukemia-associated Ptpn11 mutations. The result shows that a single Ptpn11 gain-of-function mutation evokes all major features of Noonan syndrome by acting on multiple development lineages in a gene dosage-dependent and pathway-selective manner.

Author: Bronson, Roderick T., Epstein, Jonathan A., Neel, Benjamin G., Gilliland, D. Gary, Araki, Toshiyuki, Ismat, Fraz A., Mohi, M. Golam, Williams, Ilfor R., Kutok, Jeffrey L., Yang, Wentian, Pao, Lily I.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Gene mutations, Gene mutation, Noonan syndrome

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A spatially and temporally restricted mouse model of soft tissue sarcoma

Article Abstract:

A mouse model of soft tissue sarcoma is generated in order to explore the mechanisms of sarcoma pathogenesis. It is shown that the intrinsic pathway of apoptosis is enough to mediate p53 tumor suppression in an epithelial cancer, but not in this model of soft tissue sarcoma.

Author: Korsmeyer, Stanley J., Jacks, Tyler, Bronson, Roderick T., Nielsen, G. Petur, Weissleder, Ralph, Takeuchi, Osamu, Crowley, Denise, Dinulescu, Daniela M., Miller, John B., Kirsch, David G., Grimm, Jan, Yoon, Sam S., Santiago, Philip M., Young, Nathan P., Quader, Bradley J., Chaber, Christopher J., Schultz, Christian P., Hornicek, Francis J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Epithelial cells, Tumor suppressor genes, Sarcoma, Apoptosis, Tumour suppressor genes, Clinical report

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Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin

Article Abstract:

Intermedilysin (ILY) is a cytolytic poreforming toxin that is secreted by Streptococcus intermedius. It is found to be very effective for the rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice.

Author: Bronson, Roderick T., Bin Gao, Weiguo Hu, Ferris, Sean P., Tweten, Rodney K., Gongxiong Wu, Radaeva, Svetlana, Halperin, Jose A., Xuebin Qin
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2008
Cell death, Erythrocytes, Red blood cells, Cell research, Cytological research, Ablation (Surgery)

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