Relation of alleles of the collagen type I alpha 1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women

Article Abstract:

Variations in a gene for a type of bone matrix collagen may cause a decrease in bone mineral density and increase the risk of osteoporosis-related fractures in older women. Researchers analyzed the COLIA1 gene in 1,778 postmenopausal women, and found that particular variations were associated with 2% to 6% reductions in bone mineral density and higher rates of bone fractures. Among the oldest women tested, bone density was reduced as much as 20% in those with the least-favorable variation, compared with those with the most-favorable variation.

Bones, Genetic aspects, Bone density, Postmenopausal women

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Homocysteine as a predictive factor for hip fracture in older persons

Article Abstract:

A study conducted to examine the linkage between the total homocysteine concentration and the risk of hip fracture in men and women enrolled in the Framingham Study, is presented. The results suggest that the homocysteine concentration is an important risk factor for hip fracture in older persons.

Aged, Elderly, Hip fractures

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Homocysteine levels and the risk of osteoporotic fracture

Article Abstract:

A study conducted to find out the relation between circulating homocysteine and the risk of incident osteoporotic fracture is presented. According to the results, increased homocysteine level appears to be a strong and independent risk factor for osteoporotic fractures in older men and women.

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