Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis

Article Abstract:

A 24-week randomized, open-label, noninferiority trial was conducted comparing oral mycophenolate mofetil with monthly intravenous cyclophosphamide as induction therapy for active lupus nephritis. In the 24-week trial, mycophenolate mofetil was more effective than intravenous cyclosphophamide in inducing remission of lupus nephritis and had a more favorable safety profile.

United States, Care and treatment, Clinical trials, Comparative analysis, Dosage and administration, Cyclophosphamide, Mycophenolate mofetil, Nephritis

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Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis

Article Abstract:

The drug mycophenolate mofetil can be used instead of cyclophosphamide when treating patients with lupus kidney disease. In a study of 42 patients, half took one drug and half the other, both in combination with prednisolone. Most of the serious side effects occurred in patients taking cyclophosphamide.

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Treatment of lupus nephritis -- a work in progress

Article Abstract:

The drug mycophenolate mofetil may be effective in treating lupus kidney disease with fewer side effects than other treatments. Most patients are given immunosuppressive drugs, which can have severe side effects.

Editorial

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