N-Terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease

Article Abstract:

Study is presented to determine the relationship between N-Terminal pro-brain natriuretic peptide (NT-proBNP) levels and severity of pulmonary hypertension and prospective mortality in patients with sickle cell disease (SCD). Results suggest that a high NT-proBNP level is associated with pulmonary hypertension and is a major risk factor for patients dying of SCD.

Science & research, Research, Mortality, Risk factors, Natriuretic peptides, Disease/Disorder overview

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Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease

Article Abstract:

A study is conducted to explore the role of arginase in sickle cell disease pathogenesis, pulmonary hypertension, and mortality. It is concluded that the data support a novel mechanism of disease in which hemolysis contributes to reduced nitric oxide bioavailability and endothelial dysfunction via release of erythrocyte arginase.

United States, Health aspects, Causes of, Hemolysis and hemolysins, Hemolysis, Arginase

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