Neuroactive antiretroviral drugs do not influence neurocognitive performance in less advanced HIV-infected patients responding to highly active antiretroviral therapy

Article Abstract:

The effect of antiretroviral therapy, including drugs that have good penetration in cerebrospinal fluid (CSF), on neuropsychologic performance is analyzed. It was found that the use of stable highly active antiretroviral therapy including multiple drugs that have good CSF penetration, was not associated with neuropsychologic performance.

Cerebrospinal fluid

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Persistence of neuropsychologic deficits despite long-term highly active antiretroviral therapy in patients with HIV-related neurocognitive impairment

Article Abstract:

The prevalence and predictors of persistent neuro psychologic (NP) deficits despite long-term highly active antiretroviral therapy (HAART) in patients with HIV-related neurocognitive impairment (NCI) are assessed. It is observed that 59 percent of the patients had persistent NP deficits.

Psychological aspects, Clinical report

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Safe treatment interruptions in patient with Nadir CD4 counts of more than 350 cells/muL

Article Abstract:

Clinical, immunologic, and virologic performance of patients with nadir CD4 counts of >350 cells/muL upon treatment interruption is evaluated. Results reveal that treatment interruptions in patients with nadir CD4 counts of >350 cells/muL seem safe for at least 48 weeks.

United States, HIV infection, Drug therapy, HIV infections

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