Postnatal inflammatory rat model for cerebral palsy: Too different from humans

Article Abstract:

A postnatal inflammatory rat model for cerebral palsy (CP) is studied to evaluate white matter damage (WMD) in the brain induced by a chronic stimulus that would correlate with the presence of Pre-OL (preoligodendrocytes) in human pregnancy. It is found that targeting Pre-OL maturation does not result in a discernable CP phenotype in the rat model.

United States, Causes of, Complications and side effects, Infants, Prenatal drug exposure

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No phenotype associated with established lipopolysaccharide model for cerebral palsy

Article Abstract:

The developmental, behavioral and motor outcomes in a lipopolysaccharide (LPS) model for periventicular leukomalacia (PVL) are evaluated for examining the association between histologic end point and cerebral palsy (CP) phenotype. No significant phenotypic differences consistent with the motor and cognitive damage sequelae of CP were demonstrated.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Medicine, Experimental

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No phenotype associated with established lipopolysaccharide model for cerebral palsy

Article Abstract:

The developmental, behavioral and motor outcomes in a lipopolysaccharide (LPS) model for periventicular leukomalacia (PVL) are evaluated for examining the association between histologic end point and cerebral palsy (CP) phenotype. No significant phenotypic differences consistent with the motor and cognitive damage sequelae of CP were demonstrated.

Maryland, Children, Diagnosis, Genetic aspects

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