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Glutamate release promotes growth of malignant gliomas

Article Abstract:

Research has been conducted on the glutamate neurotoxicity causing stroke, head trauma, multiple sclerosis and neirodegenerative diseases. Results indicate that the implanted glioma cell continues to secrete glutamate after the glutamate release from the brain slices.

Author: Nedergaard, Maiken, Takano, Tahakiro, Lin, Jane H.-C., Arcuino, Gregory, Gao, Qun, Yang, Jay
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Analysis, Physiological aspects, Medical research, Cells (Biology), Growth, Glutamate, Cells, Neurotoxic agents, Gliomas

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P2X7 receptor inhibition improves recovery after spinal cord injury

Article Abstract:

A study was conducted, by delivering P2X7 purine receptors (P2X7R) antagonists OxATP or PPADS to rats after acute impact injury, to assess the potential effect of P2X7R blockade in ameliorating acute spinal cord injury (SCI). The result reveals that both OxATP and PPADS significantly improved functional recovery and diminished cell death in peritraumatic zone.

Author: Nedergaard, Maiken, Goldman, Steven A., Arcuino, Gregory, Wang, Xiaohai, Lin, Jane, Li, Pingjia ;, Liu, Qing Song, Takano, Takahiro, Wan, Pinglan, Peng, Wei Wei, Xu, Qiwu
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Cell death, Spinal cord injuries

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An astrocytic basis of epilepsy

Article Abstract:

The occurrence of paroxysmal depolarization shifts after suppressing synaptic activity is studied using tetrodotoxin (TTX) and voltage-gated Ca(super 2+) channel blockers in an attempt to define the cellular basis for hypersynchronous bursting activity. A report that paroxysmal depolarization shifts could be initiated by release of glutamate from extrasynaptic sources or by photolysis of caged Ca(super 2+) in astrocytes is presented.

Author: Kang, Jian, Nedergaard, Maiken, Zielke, H. Ronald, Lin, Jane, Takano, Takahiro, Weiguo Peng, Guo-Feng Tian, Azmi, Hooman, Xiaohai Wang, Lou, Nanhong, Qiwu Xu, Oberheim, NancyAnn
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Usage, Epilepsy, Neurons, Tetrodotoxin

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Subjects list: United States, Research
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