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Recognition of tumor blood vessel normalization as a new antiangiogenic concept

Article Abstract:

Laboratory data proves that antiangiogenic therapy can normalize tumor vasculature and improve drug delivery. Evidence shows that judicious blockade of vascular endothelial growth factor (VEGF) can induce structural, functional and molecular changes in tumor vasculature.

Author: Jain, Rakesh K., Hellmann, Kurt
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Vascular endothelial growth factor, Tumor blood vessels, Tumour blood vessels

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Two - photon fluorescence correlation microscopy reveals the two - phase nature of transport in tumors

Article Abstract:

The adaptation and optimization of two - photon fluorescence correlation microscopy (TPFCM) indicates a two - phase nature of transport in tumors. TPFCM is useful as a transport parameter of drugs to the tumor.

Author: Jain, Rakesh K., Campbell, Robert B., Boucher, Yves, Alexandrakis, George; Brown, Edward B., Tong, Ricky T.; McKee, Trevor D.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Drug Delivery Systems, Usage, Fluorescence microscopy

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Subjects list: Research, United States
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