Partial treatment interruption of protease inhibitor - based highly active antiretroviral therapy regimens in HIV-infected children

Article Abstract:

A cohort of 26 perinatally HIV-infected children who discontinued the protease inhibitors (PI) component of their highly active antiretroviral therapy (HAART) because of difficulties with adherence, toxicity, or virologic breakthrough is presented. Therapy simplification by partial treatment interruption may provide a practical option in patients intolerant of or failing PI-based highly active antiretroviral therapy.

Patient outcomes, Protease inhibitors, Dosage and administration, Highly active antiretroviral therapy

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CD4 T-cell count and HIV-1 infection in adults with uncomplicated malaria

Article Abstract:

The impact of malaria parasitemia on the absolute number of peripheral CD4 cells in both HIV-1-positive and HIV-negative adults who were treated for uncomplicated confirmed malaria is discussed. Interpretation of absolute CD4 count might be biased during or just after a clinical malaria episode.

Malaria, Clinical report

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Stability and nevirapine suspension in prefilled oral syringes used for reduction of mother-to-child HIV transmission

Article Abstract:

The stability of nevirapine suspension over different storage conditions with a view to reduce mother-to-child transmission of HIV is discussed. It was found that in BaxaExcata-Med Oral Dispensers, nevirapine suspension is stable and pathogen free at varying conditions for six months.

Health aspects, Usage, Drugs, Drug therapy, Nevirapine, Drug dispensing

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