Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Article Abstract:

Research demonstrates that peripheral administration of amyloid beta-peptide antibodies to mice, transgenic for amyloid beta precursor protein with pathological features of Alzheimer disease, reduces the amyloid plaque burden and the disease attributes. Data reveal that the antibodies cross the blood-brain barrier to reach central nervous system and trigger microglial cell assisted plaque clearing.

Statistical Data Included, Usage, Central nervous system, Genetically modified mice

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Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

Article Abstract:

Two techniques are developed to microscopically image amyloid-beta peptide aggregates, called senile plaques, which are present in Alzheimer's disease. One technique uses in vivo the fluorescent histochemical dye thioflavine S; the other in vivo immunofluorescent test uses antibodies specific for amyloid beta; and hypotheses related to clearing plaques by immunotherapy were tested.

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Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

Article Abstract:

Results demonstrate that pathogenesis of Alzheimer disease is due to the accumulation of astrocytes around amyloid-beta peptides, degradation of the peptides and deficits in the astroglial clearence of the amyloid-beta peptide. Data suggest that any treatment that enhances the removal amyloid-beta peptides by astrocytes will mitigae the neurodegeneration associated with alzheimer disease.

Science & research, Astrocytes, Neurodegenerative diseases

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