Pharmacokinetic evaluation and short-term activity of stavudine, nevirapine, and nelfinavir therapy in HIV-1-infected adults

Article Abstract:

The study revealed that Nevirapine (NVP) administration did not affect the steady-state pharmacokinetic parameters of nelfinavir (NFV) or stavudine (d4T). Further results suggested that the combination of d4T, NVP and NFV induced rapid suppression of HIV-1 viral load and rises in CD4 cell count.

Science & research, Research, Stavudine, Nelfinavir

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A pharmacokinetic-pharmacodynamic model to optimize the phase lla development program of Maraviroc

Article Abstract:

A viral dynamics model is used to compare the effectiveness of in vivo viral inhibition of several doses of maraviroc. The use of model-based approach for selecting doses could accelerate drug development by replacing some arms or trials with simulations.

Analysis, Usage, Complications and side effects, Dosage and administration, Antiviral agents, Monte Carlo method, Monte Carlo methods, Pharmacology, Clinical report

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Baseline CD4+ cell count, not viral load, correlates with virologic suppression induced by potent antiretroviral therapy

Article Abstract:

An HIV patient's CD4 T cell count is a better predictor of the response to therapy than the amount of HIV in the blood. This was the conclusion of researchers who analyzed 30 studies of the treatment of HIV infection.

Physiological aspects, HIV infection, HIV infections, CD4 lymphocytes

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