Pharmacologic optimization of protease inhibitors and nonnucleoside reverse transcriptase inhibitors (POPIN)-A randomized controlled trial of therapeutic drug monitoring and adherence support

Article Abstract:

The feasibility and effectiveness of therapeutic drug monitoring (TDM) and adherence support (collectively, AT) versus standard of care (SOC) in patients receiving HIV protease inhibitors (PIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) within a nurse- led clinic is evaluated. The pharmacologic optimization of PIs and NNRTIs (POPIN) study confirms that TDM trials are complex to interpret and statistically underpowered, with effectiveness better assessed through the clinical utility of a TDM result, whether normal or abnormal.

Health aspects, Care and treatment, Methods, Patient outcomes, Protease inhibitors, Anti-HIV agents, Patient monitoring, Physiologic monitoring

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The pharmacology of antiretroviral nucleoside and nucleotide reverse transcriptase inhibitors: Implications for once-daily dosing

Article Abstract:

Nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) is a prime focus for developing once-daily therapies primarily as they form the backbone of most existing regimens. Clinicians require an understanding of the plasma and intracellular pharmacokinetics properties of NRTIs to construct simplified and effective therapies for individual patients.

Reverse transcriptase inhibitors

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Effectiveness and safety of abacavir, lamivudine, and zidovudine in antiretroviral therapy - Naive HIV-infected patients

Article Abstract:

The study is conducted to analyze the safety and effectiveness of abacavir, lamivudine, and zidovudine (ABC/3TC/ZDV) in antiretroviral therapy (ART)-naive HIV-infected patients. The triple-nucleoside regimen of (ABC/3TC/ZDV) is a reasonable option for ART-naive patients with a plasma HIV-1 viral load (pVL) <100,000 copies/mL.

General services, Safety and security measures, Lamivudine, Abacavir

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