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Physician Interpretations and Textbook Definitions of Blinding Terminology in Randomized Controlled Trials

Article Abstract:

Many doctors are not clear about what constitutes single, double, and triple blinding in a research study and medical textbooks are not much help. This was the conclusion of researchers who surveyed 91 doctors and consulted 25 textbooks. In a research study, blinding means that one or more groups of people participating in the study do not know which patients receive which treatment.

Author: Guyatt, Gordon H., Devereaux, P. J., Manns, Braden J., Ghali, William A., Quan, Hude, Lacchetti, Christina, Montori, Victor M., Bhandari, Mohit
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
Medical research, Terminology

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Comparison of 2 Methods for Calculating Adjusted Survival Curves From Proportional Hazards Models

Article Abstract:

Researchers should use the corrected group prognosis method for estimating patient survival curves rather than the mean of covariates method. The latter method can provide misleading data. Survival curves are generated to estimate the predicted survival of two or more groups of patients.

Author: Brant, Rollin, Ghali, William A., Quan, Hude, Melle, Guy van, Norris, Colleen M., Faris, Peter D., Galbraith, P. Diane, Knudtson, Merril L.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
Research, Evaluation, Medical statistics, Outcome and process assessment (Health Care), Outcome and process assessment (Medical care)

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Randomized trials stopped early for benefit

Article Abstract:

The epidemiology and reporting quality of randomized clinical trials (RCTs) involving interventions stopped early for benefit is evaluated. RCTs stopped early for benefits are becoming more common, often fail to adequately report relevant information about the decision to stop early and give implausibly large treatment effects.

Author: Guyatt, Gordon H., Cook, Deborah J., Lacchetti, Christina, Montori, Victor M., Burns, Karen E.A., Eggert, Christoph H., Darling, Elizabeth, Thompson, Carly A., Devereaux, P.J., Adhikari, Neill K.J., Briel, Matthias, Leung, Teresa W., Schunemann, Holger J., Meade, Maureen O., Bryant, Dianne M., Bucher, Heiner C., Erwin, Patricia J., Sood, Amit, Sood, Richa, Lo, Benjamin, Qi Zhou, Mills, Edward
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
United States, Management dynamics, HEALTH SERVICES, Management, Health care industry, Company business management

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Subjects list: Clinical trials
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