Platelet intracellular free calcium response to arginine vasopressin is similar in preeclampsia and normal pregnancy

Article Abstract:

The amount of unbonded cytoplasmic calcium in platelet cells does not appear to serve as a marker for preeclampsia. Abnormal platelet function is characteristic of preeclampsia, and a rise in free calcium in the cytoplasm plays a role in platelet function when platelets are activated. Another study found elevated free calcium in platelets of preeclamptic women. Blood samples were compared among 10 nonpregnant women, 10 women with preeclampsia and 10 healthy pregnant women matched for age and gestational length, and 64 normal pregnant women at 28 weeks gestation. All pregnant women had not given birth previously. Platelets were separated out and free calcium concentration within platelet cells was assayed both before and after platelet stimulation with arginine vasopressin. No differences were found among the groups.

Research, Calcium in the body, Calcium (Nutrient), Blood platelets, Platelet activation, Vasopressin, Vasopressins

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Vascular smooth muscle oxygen consumption is reversibly stimulated by sera from women with preeclampsia

Article Abstract:

There appears to be some chemical in the blood of pregnant women with preeclampsia that increases oxygen consumption in blood vessels. Preeclampsia is a complication of pregnancy that causes hypertension and blood vessel constriction. Researchers exposed blood vessels from pigs to blood samples from pregnant women with preeclampsia, healthy pregnant women and healty non-pregnant women. The blood from women with preeclampsia caused the blood vessels to use more oxygen compared to blood from the other groups. Rinsing the blood vessels brought oxygen consumption back to normal levels.

Oxygen consumption, Oxygen consumption (Metabolism), Smooth muscle

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Preeclampsia: an excessive maternal inflammatory response to pregnancy

Article Abstract:

Preeclampsia may be an excessive case of generalized inflammation that normally occurs during pregnancy. If so, there may be no way to prevent preeclampsia or even to predict which pregnant women may develop it. Preeclampsia is characterized by high blood pressure, abnormal blood clotting, and mild kidney abnormalities. It has been linked to abnormal functioning of the endothelium, which is the inner lining of blood vessels. Many of the changes that occur in preeclampsia can be seen in a normal pregnancy at a much lower level of activation.

Pregnancy

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