Platelets mediate cytotoxic T lymphocyte-induced liver damage

Article Abstract:

A result that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage acute viral hepatitis is described. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease.

Care and treatment, Hepatitis, Viral, Viral hepatitis, Blood platelets, Platelet transfusion

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Broadly neutralizing antibodies protect hepatitis C virus quasispecies challenge

Article Abstract:

Several broadly neutralizing antibodies that protect against the hepatitis C virus (HCV) are discussed. The analysis shows that these antibodies neutralize the genetically diverse HCV isolates and hence helps protect against HCV quasispecies challenge.

Control, Monoclonal antibodies, Immunotherapy, Hepatitis C virus

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Lymphopenia and interleukin-2 therapy alter homeostasis of CD4(super +)CD25(super +) regulatory T cells

Article Abstract:

CD4(super +)CD25(super +) regulatory T (T(sub reg)) cells have a crucial role in maintaining immune tolerance. T(sub reg) cells are monitored during immune reconstitution in individuals with cancer who did not receive IL-2 therapy.

Interleukin-2, Lymphocytopenia

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