Thromboxane mediates neutrophil superoxide production in pregnancy

Article Abstract:

The possibility of thromboxane playing a role in neutrophil superoxide generation in pregnancy by inhibiting key enzymes in the pathway leading to its synthesis, namely thromboxane synthase, cyclooxygenase-2 (COX) and phospholipase [A.sub.2], is tested. The results have shown that thromboxane is involved in the production of superoxide by neutrophils obtained from pregnant women and also neutrophil superoxide generation is decreased by inhibition of thromboxane synthase, cyclooxygenase-2, or phospholipase [A.sub.2].

Health aspects, Pregnant women, Neutrophilia, Clinical report

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Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha response to linoleic and oxidative stress

Article Abstract:

Study is conducted to evaluate whether linoleic acid under conditions of oxidative stress would stimulate neutrophil production of thromboxane and tumor necrosis factor-alpha. Results demonstrate that exposure of neutrophils from normal pregnant women to conditions present in preeclamptic women results in neutrophil activation with release of thromboxane and tumor necrosis factor-alpha.

Neutrophils

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The association between inherited cytokine polymorphisms and cerebral palsy

Article Abstract:

A study was conducted to investigate associations between inherited cytokine polymorphisms and cerebral palsy. The result showed that carriage of polymorphisms in the tumor necrosis factor-alpha and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.

Cerebral palsy, Genetic aspects, Genetic polymorphisms, Cytokines

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