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Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer

Article Abstract:

A randomized phase 1/2 study in lymphopenic individuals is performed after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for myeloma. In the setting of lymphopenia, combined vaccine therapy and adoptive T-cell transfer fosters the development of enhanced memory T-cell responses.

Author: Stadtmauer, Edward A., Sickles, Cheryl, Porter, David L., Zhang, Lei, June, Carl H., Edelman, Robert, Cross, Alan, Rapoport, Aaron P., Aqui, Nicole, Badros, Ashraf, Cotte, Julio, Chrisley, Lisa, Veloso, Elizabeth, Zheng, Zhaohui, Westphal, Sandra, Mair, Rebecca, Chi, Nina, Ratterree, Bashi, Pochran, Mary Francis, Natt, Sabrina, Hinkle, Joanne, Sohal, Ambika, Ruehle, Kathleen, Lynch, Christian, Luger, Selina, Guo, Chuanfa, Fang, Hong-Bin, Blackwelder, William, Hankey, Kim, Mann, Dean, Frasch, Carl, Levine, Bruce L.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
T cells, Hematopoietic stem cells, Hematopoietic stem cell transplantation

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Article Abstract:

A study to show that inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity is presented. Stat3 signaling restrains natural tumor immune surveillance and inhibiting hematopoietic stat3 in tumor-bearing hosts elicits multicomponent therapeutic antitumor immunity.

Author: Pardoll, Drew, Jove, Richard, Hua Yu, Kortylewski, Marcin, Kujawski, Maciej, Tianhong Wang, Sheng Wei, Shumin Zhang, Pilon-Thomas, Shari, Guilian Niu, Kay, Heidi, Mule, James, Kerr, William G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
United States, Immunosuppressive agents, Hematopoietic agents

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

Article Abstract:

Tumor progression involves processes such as tissue invasion that can activate inflammatory responses, the immune system largely ignores or tolerates disseminated cancers. It is reported that constitutive activation of Stat-3 in tumor cells increases expression of proinflammatory mediators.

Author: Heller, Richard, Pardoll, Drew, Wang, Tianhong, Niu, Guilian, Burdelya, Lyudmila, Shain, Kenneth, Zhang, Shumin, Bhattacharya, Raka, Gabrilovich, Dmitry, Coppola, Domenico, Eltinge, Julian, Jove, Richard, Hua Yu
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Development and progression, Tumors, Immune response, Tumours

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Subjects list: Research, Cancer, Cancer treatment
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