Pregnancy potential of human oocytes - the effect of cryopreservation

Article Abstract:

In vitro fertilization (a procedure in which fertilization of the human egg occurs under laboratory conditions, prior to implantation into the uterus) is now a routine way of treating infertility; currently, though, only 25 percent of egg collections ultimately result in pregnancy. It is possible that this rate is a function of some aspect of the in vitro fertilization technique, and the outcome from implantation of previously frozen (cryopreserved) versus fresh embryos was compared in this regard. To evaluate this, donated eggs were fertilized in vitro, and the embryos either frozen for later implantation, or implanted immediately. The protocol was such that two thirds of a donor's eggs were allocated to the donor herself (32 women), and the resulting embryos always implanted fresh. The remaining eggs went to other recipients (57 women), in which cases the resulting embryos were implanted either fresh or after cryopreservation. Eggs were implanted in 40 consecutive cycles, of which pregnancy occurred in 25, for a rate of 63 percent. In 9 cycles, either the donor or the donor and the recipients conceived; in 16 cycles, only the recipients conceived. Seventeen embryos were transferred fresh to non-donor recipients; of these, 13 (76 percent) became pregnancies. The remaining 23 embryos were cryopreserved: these led to 12 pregnancies (52 percent). Fresh embryos also had a higher rate of implantation than frozen and thawed embryos (24 versus 7.7 percent). The pregnancy rate in the group that received fresh embryos was 37 percent, compared with 15 percent for those that received previously frozen embryos. The results indicate that most cohorts of eggs (the group of eggs harvested from one woman at one time) could result in pregnancy under favorable conditions. These conditions are outlined. (Consumer Summary produced by Reliance Medical Information, Inc.)

Methods, Evaluation, Complications and side effects, Fertilization in vitro, Human, Human fertilization in vitro, Cryopreservation of organs, tissues, etc., Organ cryopreservation, Tissue cryopreservation

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Bit player or powerhouse? China and stem-cell research

Article Abstract:

China appears to be accumulating substantial expertise in the area of stem-cell research, but does not have the infrastructure as yet that scientific breakthroughs in stem-cell science are likely to require. However, in the future, China may well become a powerhouse in the international stem-cell sector, able to leverage its talents, scale, and cost advantages to push the science out of the laboratories and into the clinics.

China, Government domestic functions, Forecasts, trends, outlooks, Forecasts and trends, Science and technology policy, Market trend/market analysis, Stem cell research

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The egg trade - Making sense of the market for human oocytes

Article Abstract:

The demand for human oocytes, for reproduction as well as for research, is growing rapidly in the U.S., along with the debates on the issues raised by egg donation. The most critical issues that must be addressed are the health risks faced by the donors, the need to ensure that potential donors are fully informed of the risks, and the decision to provide monetary compensation for egg donation.

United Kingdom, Market information - general, Labor Distribution by Employer, Supply and demand, Statistics, Oocytes, Oocyte donation

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