Preliminary study of the efficacy of insulin aerosol delivered by oral inhalation in diabetic patients

Article Abstract:

Oral inhalation of aerosolized insulin may be effective in the treatment of patients with non-insulin dependent diabetes (NIDDM). Six non-obese, nonsmoking patients with NIDDM began insulin inhalation with approximately 1 Unit of insulin per kilogram of body weight. Fifty percent to 93% of the inhaled dose was deposited in the lungs of all six patients, and the average deposition below the larynx was 79%. Blood sugar levels significantly dropped in all six patients after insulin inhalation, and they dropped to within the normal range in five patients. The patients tolerated the aerosolized insulin well, and no adverse reactions, including coughing, were reported. Although further studies are needed, inhalation may prove to be a safe and simple alternative to the injection of insulin.

Evaluation, Insulin, Drug delivery devices

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Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: A randomized trial

Article Abstract:

A randomized controlled trial is used to evaluate the effect of pioglitazone vs glimepiride on changes in carotid artery intima-media thickness (CIMT) of the common carotid artery in patients with type 2 diabetes mellitus (DM). The results have shown that over an 18-month treatment period in patients with type 2 DM, pioglitazone slowed the progression of CIMT when compared to glimepiride.

Glimepiride, Clinical report, Pioglitazone

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Liver Enzyme Monitoring in Patients Treated With Troglitazone

Article Abstract:

Many doctors do not know of, or do not follow, FDA advisories. When the diabetic drug troglitazone was found to cause liver failure, the manufacturer sent letters to all doctors recommending monthly liver tests for all patients taking the drug. However, a study of 7,603 patients who were taking the drug found that less than 5% received all of the recommended liver tests.

Causes of, Complications and side effects, Liver failure, Troglitazone

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