Preterm labor and bacterial intraamniotic infection: arachidonic acid liberation by phospholipase A2 of Fusobacterium nucleatum

Article Abstract:

The bacterium Fusobacterium nucleatum appears to be capable of producing substances that can cause labor. Many researchers believe infection may be one of the causes of premature labor. Researchers exposed samples of uterine tissue to the bacterium and found that the bacterium stimulated the production of arachidonic acid. Arachidonic acid is a precursor of prostaglandins, which are involved in labor induction. This adds further evidence to the claim that premature labor and premature rupture of membranes can be caused by infection.

Causes of, Physiological aspects, Arachidonic acid, Bacterial infections, Premature labor

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Evidence for tight coupling of Gi protein-mediated lysophosphatidic acid receptor to stimulated cytokine production in ovarian cancer cell

Article Abstract:

The G-protein subtypes that are linked to lysophosphatidic acid (LPA) receptor in cytokine production, which are involved in ovarian cancer development, are identified. The Gi protein that couples LPA receptor to the effector defines the differences in signaling pathways of LPA-activated cytokine expression and proliferation.

Risk factors, Proteins, Cytokines, Adenosine diphosphate

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Translocation of lysophosphatidic acid phosphatase in response to gonadotropin-releasing hormone to the plasma membrane in ovarian cancer cell

Article Abstract:

The hormonal translocation of lipid phosphate phosphatase type 3 to the plasma membrane in gonadotropin-releasing hormone-responsive ovarian cancers is examined. The lipid phosphate phosphatase type 3 protein was found in the cytoplasm and at the plasma membrane in Caov-3 and SK-OV-3 cells.

Analysis, Gonadotropin releasing hormone, Gonadorelin

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