Problems in the Design and Reporting of Trials of Antifungal Agents Encountered During Meta-analysis

Article Abstract:

All medical researchers should keep copies of their data when conducting clinical trials. This will ensure that other researchers will have complete data when and if they use those trials in meta-analyses. Meta-analysis is a technique used to combine the results of many different clinical trials into one large trial. However, many of the individual trials may have used different techniques or different methods. Researchers who conducted a meta-analysis of antifungal drugs used to treat cancer patients discuss the various problems that may arise.

Antifungal agents

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Data extraction errors in meta-analyses that use standardized mean differences

Article Abstract:

The study results to determine the accuracy of standardized mean differences in meta-analysis indicate that data extraction is particularly liable to errors that could negate or even reverse the findings of the study, hence such meta-analyses should be approached with caution.

United States, Analysis, Information management, Information accessibility, Clinical report

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Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment

Article Abstract:

Placebos should not be used therapeutically except possibly for the treatment of pain. A review of 114 studies that compared a placebo to no treatment found no substantial benefits except in the 27 studies of pain treatments.

Care and treatment, Pain, Pain management, Placebos

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