Targeting tumors through the HIF system

Article Abstract:

Research suggests that hypoxia-inducible factor (HIF) may be useful as a component of new cancer therapeutics. HIF regulates cellular response to hypoxia in many cancers, and blocking the upregulation pathway could yield new approaches to treating cancerous tumors.

United States, Genetic aspects, Cancer cells, Tumors, Pathology, Cellular, Cytopathology

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Regulation of angiogenesis by hypoxia: role of the HIF system

Article Abstract:

An important component of homeostatic mechanisms are the regulation of angiogenesis by hypoxia that link vascular oxygen supply to metabolic demand. The role of HIF in developmental, adaptive and neoplastic angiogenesis is reviewed and the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype are discussed.

Science & research, Neovascularization, Homeostasis

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HIF, a missing link between metabolism and cancer

Article Abstract:

An investigation on the way loss-of-function mutations in fumarate hydratase or succinate dehydrogenase lead to the activation of hypoxia-inducible factor (HIF) is conducted. This oxygen-dependent reaction is required for degradation of HIF and von Hippel-Lindau (VHL), and therefore, acts as an oxygen sensor that governs HIF stability.

Health aspects, Care and treatment, Von Hippel-Lindau disease

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