Role of COL4A1 in small-vessel disease and hemorrhagic stroke

Article Abstract:

Small-vessel diseases of the brain underlie 20 to 30 percent of ischemic strokes and a larger proportion of intracerebral hemorrhages. A mutation in the mouse Col4A1 gene, encoding procollagen type IV alpha1, predisposes both newborn and adult mice to intracerebral hemorrhage, and a COL4A1 mutation in a human family with small-vessel disease is identified that might cause a spectrum of cerebrovascular phenotypes.

United States, Science & research, Research, Causes of, Stroke (Disease), Stroke, Membrane proteins

---

Hemiplegic migraine -- downstream of a single-base change

Article Abstract:

Studies of hemiplegic migraine show that people with the same gene mutation can have very different symptoms. This type of migraine is caused by a mutation in the calcium channel gene CACNA1A. The symptom variability illustrates the effect of environment and development on the human brain.

Editorial, Abnormalities, Calcium channels

---

The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel

Article Abstract:

Nine different gene mutations are responsible for causing familial hemiplegic migraine, which could account for the variety of symptoms. This type of migraine has a clear hereditary basis and usually causes some form of reversible paralysis during attacks.

Familial diseases

Similar abstracts:

• Abstracts: The apple of your eye: this low-fat dessert is easier than you think. Roll up for flavor
• Abstracts: Screening for cardiac disease in patients having noncardiac surgery. Prediction of perioperative risk: the glass may be three-quarters full
• Abstracts: Prognostic importance of comorbidity in a hospital-based cancer registry. Obstructive Sleep Apnea
• Abstracts: APOE polymorphisms and late-onset Alzheimer disease: the importance of ethnicity. Association Between Apolipoprotein E [epsilon]4 and Sleep-Disordered Breathing in Adults
• Abstracts: Thin end of the wedge? Here's another starter for 10

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.