Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza

Article Abstract:

A chemical that inhibits the enzyme neuraminidase in the influenza virus may protect against the disease and reduce symptoms in those who have it. Neuraminidase is important in viral reproduction and probably allows the virus to penetrate respiratory epithelial cells. Four studies tested the chemical GG167 on 160 people to see if the chemical could prevent influenza or reduce its symptoms. Some studies gave GG167 nose drops to the volunteers four hours before they were experimentally infected with the influenza A virus and some gave the GG167 drops 1 to 2 hours after infection. Altogether, 112 got the GG167 drops and 48 volunteers got a placebo. GG167 significantly reduced viral shedding and the incidence of influenza in those who received it prophylactically. It also significantly reduced symptoms in those who received it after developing influenza. There were no significant side effects.

Evaluation, Enzyme inhibitors

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Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: A randomized controlled trial

Article Abstract:

The dose-related safety, immunogenicity, and protective efficacy of an experimental trivalent influenza virus hemagglutinin (rHAO) vaccine produced in insect cells were determined using recombinant baculoviruses. The findings suggested that it is possible to generate a substantial amount of protection in an immunologically primed population against influenza with a pure hemagglutinin vaccine, even in the presence of significant antigenic drift.

United States, Influenza vaccines, Human immunogenetics, Baculoviruses, Clinical report

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Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial

Article Abstract:

A double-blind, randomized controlled trial was conducted to compare the vaccination success rate and the reaction profile of various Aventis Pasteur smallpox vaccine (APSV). ASPV was found as an effective vaccine even at diluted doses allowing for expansion of the current stockpile while, reactogenicity was found not reduced with dilution of the vaccine and as with other smallpox vaccine may impair daily activities.

Health aspects, Smallpox vaccine, Smallpox vaccines

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