Sequence of neuronal responses assessed by immunohistochemistry in the newborn rat brain after hypoxia-ischemia

Article Abstract:

Heat shock protein-72 (HSP-72) and microtubule-associated protein-2 (MAP-2) levels appear to reflect cell damage seen after oxygen deprivation in an area of the brain called the hippocampus. HSP-72 and MAP-2 levels were measured in the brains of seven-day-old rats killed at designated time points between one and 72 hours after the main blood vessel supplying oxygen to one half of the brain was tied off. Brain damage was examined microscopically after death. HSP-72 levels peaked and MAP-2 levels reached their lowest point 24 hours after injury. Most of the brain damage occurred in the CA3 region of the hippocampus.

Injuries, Measurement, Hippocampus (Brain), Brain damage

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Heat shock protein 70 and heat shock cognate protein 70 messenger ribonucleic acid induction in the brains, hearts, and livers of neonatal rats after hypoxic stress

Article Abstract:

The fetus may produce a protein called heat shock cognate protein 70 under stressful conditions to protect the heart and brain from damage. Researchers measured the amount of this protein in the heart, brain, and liver of seven-day-old rats who had been subjected to low levels of oxygen. This caused blood oxygen levels and brain temperature to drop. It also caused the level of heat shock cognate protein 70 to increase in brain and heart but not in liver.

Fetus

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Limited differentiation to neurons and astroglia from neural stem cells in the cortex and striatum ischemia/hypoxia in the neonatal rat brain

Article Abstract:

A study is conducted to examine whether progenitor neutral cells can differentiate successfully into mature neutrons and atrocities in a rat model of neonatal hypoxic-ischemic encephalopathy. The intrinsic ability for neurologic self-repair is limited at the maturation step after hypoxic-ischemic stress in the neonatal rat brain.

United States, Science & research, Research, Stem cells, Ischemia, Astrocytes, Fetal brain

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