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Small sac size in the first trimester: a predictor of poor fetal outcome

Article Abstract:

Up to 25 percent of clinically recognized pregnancies end in a spontaneous (natural) abortion. Once a fetal heartbeat is detected, the risk of spontaneous abortion decreases dramatically, occurring in only 2 to 4 percent of pregnancies. It is not clear whether there are indicators of a possible spontaneous abortion once the heartbeat has been established. Some evidence exists that a small embryonic sac size during the first trimester of pregnancy, even when the fetal heartbeat is present, indicates a higher risk of spontaneous abortion. This study followed 17 pregnancies in which a fetal heartbeat was present but so was a small sac during the first trimester. A group of 52 pregnancies where sac size was normal was also followed for purposes of control. A small sac size was determined to be a difference between mean sac size (MSS) and crown-rump lengths (CR) of less than 5 mm. Results found that in the small sac group, spontaneous abortion occurred in 15 of the 16 pregnancies (94 percent) compared with 4 of 52 (8 percent) in the control group. These results indicate that once a fetal heartbeat has been established, a small sac size during the first trimester is a good indicator of a probable poor outcome of the pregnancy. (Consumer Summary produced by Reliance Medical Information, Inc.)

Author: Harlow, Bernard L., Benacerraf, Beryl R., Bromley, Bryann, Laboda, Lane A.
Publisher: Radiological Society of North America Inc.
Publication Name: Radiology
Subject: Health
ISSN: 0033-8419
Year: 1991
Ultrasound imaging, Diagnosis, Measurement, Risk factors, Human embryo, Pregnancy, Complications of, Pregnancy complications, Miscarriage

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Evaluation of a population roster as a source of population controls: the Massachusetts Resident Lists

Article Abstract:

A study reports that more than 90% of the members of a study group of Massachusetts women having ovarian cancer were included on the Massachusetts Resident Lists. The authors state that population lists may provide a good source of population controls for case studies.

Author: Spiegelman, Donna, Harlow, Bernard L., Mueller, Nancy E., Cramer, Daniel W., Bohlke, Kari
Publisher: Johns Hopkins University Press
Publication Name: American Journal of Epidemiology
Subject: Health
ISSN: 0002-9262
Year: 1999
United States, Massachusetts, Usage, Case studies, Ovarian cancer, Census, Censuses, Epidemiological research, Cross sectional studies

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Prevalence and predictors of chronic lower genital tract discomfort

Article Abstract:

About one in five women may have chronic genital tract discomfort, according to a survey of 303 women. Symptoms can range from itching and burning to excessive pain on contact. Many women are too embarrassed to report these symptoms to their doctor.

Author: Harlow, Bernard L., Wise, Lauren A., Stewart, Elizabeth G.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001
Genital diseases, Female, Female genital diseases

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Subjects list: Statistical Data Included, Statistics
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