(Super)1H magnetic resonance spectroscopy reveals neuronal injury in a simian immunodeficiency virus macaque model

Article Abstract:

Monkeys infected with simian immunodeficiency virus (SIV) appear to develop a condition similar to AIDS dementia complex. This was revealed by a study using (super)1H magnetic resonance spectroscopy to measure N-acetylaspartate (NAA) in samples of brain tissue from Rhesus monkeys infected with SIV. NAA is found only in the nervous system and reduced levels are a sign of nerve damage. NAA levels were significantly lower in 9 SIV-infected monkeys compared to 6 uninfected monkeys. Medical examination of the brain tissue samples revealed that 6 of the 9 SIV-infected monkeys had evidence of nerve damage.

Models, Usage, Physiological aspects, Magnetic resonance imaging, Central nervous system diseases, AIDS dementia, AIDS dementia complex

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The clinical epidemiology of human T-lymphotropic virus type II (HTLV-II)

Article Abstract:

Much research needs to be done on the human T-lymphotropic virus type II (HTLV-II), which has been overshadowed by its cousin, HTLV-I. HTLV-II is widespread among American Indian tribes in North, South and Central America. It has also been found in intravenous drug addicts and their sexual partners and in people who have received blood transfusions. It can also be transmitted via breast milk. There are an estimated 140,000 HTLV-II carriers in the US alone. The most well-documented disease associated with HTLV-II is a muscle disease similar to HTLV-I-associated myelopathy (HAM).

Causes of, Demographic aspects, HTLV-II infections, Muscle diseases, Muscular diseases

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Sequence variation and subtyping of human and simian T-cell lymphotropic virus type 1 strains from South Africa

Article Abstract:

Gene sequencing of viral isolates from several South African patients infected with human T cell lymphotropic virus type I (HTLV-I) indicates that the viruses belong to the Cosmopolitan viral subtype as opposed to the West African or Central African subtypes. Analysis of strains of simian T cell lymphotropic virus type I (STLV-I) from the vervet monkey revealed they were more closely related to chimpanzee strains than other green monkey strains.

Genetic aspects, HTLV-I (Virus)

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