Suppressing a sick heart

Article Abstract:

A novel negative regulatory pathway governing pathologic cardiac growth is represented by the NGFI-A binding protein (NAB1)-early growth response (Egr) interaction. NAB1 is a transcriptional repressor that interacts directly with the transcription factor Egr-1 and helps in the negative regulation of pathologic cardiac hypertrophy.

United States, Genetic aspects, Heart enlargement, Heart hypertrophy, Binding proteins

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Transcription factor Ggr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth

Article Abstract:

RNA -cleaving phosphodiester- linked DNA- based enzymes, targeting a specific motif in the 5' untranslated region of early growth response mRNA, inhibit Egr-1 protein expression, microvascular endothelial cell replication and migration, and microtubule network formation on basement membrane matrices.

Neovascularization, RNA

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New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

Article Abstract:

A DNA enzyme that cleaves early growth response factor-1 (Egr-1) inhibits cell proliferation and wound repair. This enzyme would be useful for treating patients with atherosclerosis, which is caused partly by abnormal cell proliferation and wound repair.

Prevention, Enzymes, Growth factors, Cell proliferation

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