Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Article Abstract:

Research shows that selective disruption of glucose transporter, involved in the transmembrane transport of glucose, results in a significant reduction in basal glucose transport with no stimulation by subsequent insulin infusion in mice. Data further indicate that mice exhibit insulin resistance and glucose intolerance suggesting that glucose transport helps maintain glucose homeostasis.

Statistical Data Included, Analysis, Blood sugar, Blood glucose, Metabolic regulation, Glucose tolerance tests, Glucose tolerance test, Gluconeogenesis

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mTOR tells the brain that the body is hungry

Article Abstract:

A demonstration that mammalian target of rapamycin (mTOR) responds to nutritional states in a subset of hypothalamic neurons that are important for feeding control is presented. mTOR activation in the hypothalamus is required for the appetite-suppressing response to leptin and to central nervous system (CNS) administration of leucine, a branched-chain amino acid (BCAA) known to potently stimulate mTOR.

Science & research, Research, Brain research, Leucine, Rapamycin, Appetite, Appetite (Psychophysiology), Hypothalamic hormones

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Fat fuels insulin resistance through toll-like receptors

Article Abstract:

A study proposes that Toll-like receptors (TLRs) in mammals, which are capable of defending against tuberculosis and other microbial disease, are also involved in initiating inflammatory responses in response to dietary lipids. The findings add a new link to the growing evidence that inflammatory processes might be responsible for insulin resistance associated with obesity.

Health aspects, Obesity

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