Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics

Article Abstract:

This article examines gene therapy research, focusing on the use of viruses to transfer therapeutic foreign genetic material into cells. Topics addressed include viral genetic engineering, recombinant viral vectors, and genetic transfer in retroviruses, lentiviruses, adenoviruses, adeno-associated virus, and herpes simplex virus.

United States, Genetic vectors, Adenoviruses, Retroviruses, Herpes simplex virus, Virus-vector relationships

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Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

Article Abstract:

The promising targets for the activity and the selective delivery of cancer therapeutics are angiogenic tumor vessels. A vehicle for the transport of gene therapy to tumors may be represented by a transplantation of genetically modified bone marrow progenitors.

Bone marrow transplantation, Neovascularization

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Inserting optimism into gene therapy

Article Abstract:

The gene therapy is successful in clinical trials in children affected by rare inherited disorders that cause severe combined immunodeficiency (SCID). Some of the children treated for the X-linked form of SCID were later diagnosed with leukemia consequent to oncogene activation at a vector insertion site but no adverse effects were reported in trials with another type of SCID (ADA-SCID) though setback has raised serious concerns about the safety of the technique.

Care and treatment, Clinical trials, Genetic aspects, Severe combined immunodeficiency

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