Targeting of CD44 eradicates human acute myeloid leukemic stem cells

Article Abstract:

A study was conducted to show that CD44 is a key regulator of acute myeloid leukemia-leukemia stem cells (AML LSC) function that is essential for proper homing of AML-LSCs to microenvironmental niches and for maintaining AML LSCs in primitive state. Manipulation of CD44 function with the H90 mAb resulted in marked reduction of the leukemic burden in NOD-SCID mice transplanted with primary AML cells and it is possible to target AML LSCs by focusing on their stem cell properties rather than proliferation.

Care and treatment, Causes of, Stem cells

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Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

Article Abstract:

A study was conducted to show that CD44 expression is increased on mouse stem-progenitor cells expressing BCR-ABL and that CD44 contributes functional E-selection ligands. The results show that BCR-ABL-expressing leukemic stem cells depend to a greater extent on CD44 for homing and engraftment than do normal hematopoietic stem cells (HSCs), and CD44 blockage might be beneficial in autologous transplantation in chronic myeloid leukemia (CML).

Hematopoietic stem cells, CD4 lymphocytes, Leukemia research

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Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia

Article Abstract:

Ligation of CD44 with specific anti-CD44 monoclonal antibodies or with hyaluronan has been found to be able to reverse myeloid differentiation blockage in acute myeloid leukemia (AML)1/2 - AML5 subtypes. Hyaluronan is the natural ligand of CD44. Differentiation of AML blasts was seen from expression of lineage antigens, ability to bring oxidative bursts, and cytological changes. These are specific to normal differentiated myeloid cells.

France, Physiological aspects, Glycoproteins, Lymphocyte transformation, Cell differentiation, Monoclonal antibodies, Hyaluronic acid, Cell research, Cytological research, Acute leukemia, Promyelocytic

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