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The history of malariotherapy for neurosyphilis: modern parallels

Article Abstract:

Scientists are changing the way AIDS research is done at the request of AIDS activists, but in doing so they may be returning to the time when scientific research was incapable of determining whether a treatment was effective. In 1917, the Austrian doctor Julius Wagner-Jauregg decided to inject syphilis patients with blood from malaria patients in the belief that the resultant fever would kill the syphilis bacterium. He claimed great success, as did the doctors who repeated his experiments. However, the idea of using a control group - patients who did not receive the treatment - was unknown at that time. Although Wagner-Jauregg received the Nobel Prize in 1927, malariotherapy was never conclusively proved to cure syphilis by today's research standards. If current research standards are abandoned in the search for a cure for AIDS, it will be impossible to prove conclusively that the treatments are effective.

Author: Stolley, Paul D., Austin, Stephanie C., Lasky, Tamar
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
Standards, History, Medical research, AIDS (Disease), Neurosyphilis, Malariotherapy

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The Guillain-Barre syndrome and the 1992-1993 and 1993-1994 influenza vaccines

Article Abstract:

The risk of contracting Guillain-Barre syndrome from influenza vaccines appears to be relatively small. This syndrome is characterized by a reversible paralysis and has been linked to several vaccines. Researchers analyzed vaccination rates among 180 people diagnosed with Guillain-Barre syndrome during the 1992-1993 and 1993-1994 influenza seasons. Nineteen had been vaccinated against influenza in the six weeks before developing the syndrome. This translates to a 50% to 70% increase in risk, or one case of Guillain-Barre syndrome for each one million people vaccinated against influenza.

Author: Chen, Robert T., Nash, Denis, Schonberger, Lawrence B., Stolley, Paul D., Lasky, Tamar, Magder, Laurence, Haber, Penina, Terracciano, Gina J., Koski, Carol Lee, Ballesteros, Michael, Clark, Shelley
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Complications and side effects, Risk factors

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Guillain-Barre' syndrome following influenza vaccination

Article Abstract:

A study was conducted to evaluate trends of reports to Vaccine Adverse Events Reporting System (VAERS) of Guillain-Barre' syndrome (GBS) following influenza vaccination in adults. It was revealed that from 1990 to 2003, VAERS reporting rates of GBS after influenza vaccination decreased.

Author: DeStefano, Frank, Chen, Robert T., Iskander, John, Weintraub, Eric, Haber, Penina, Angulo, Fredrick J., Shadomy, Sean V.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
United States, Usage, Influence, Surveys

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Subjects list: Care and treatment, Influenza vaccines, Guillain-Barre syndrome
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