A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia

Article Abstract:

It may not be necessary to monitor fetal blood samples to prevent brain hemorrhages in fetuses of mothers who are producing antibodies against fetal platelets. Immunoglobulin and platelet transfusions can still be given, according to a study of 56 pregnancies.

Prevention, Brain, Hemorrhage, Brain hemorrhage, Fetal diseases

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The immunologic profile of infants born after maternal immunoglobulin treatment and intrauterine platelet transfusions for fetal/neonatal alloimmune thrombocytopenia

Article Abstract:

The aim of this study was to evaluate the potential effects of antenatal treatment for fetal/neonatal alloimmune thrombocytopenia on the developing immune system through analysis of lymphocyte subsets in cord blood and to compare these with healthy controls. Our results suggest that intrauterine platelet and, in particular, red cell transfusions cause more immune deviations than treatment with intravenous immunoglobulin.

Science & research, Research, Immunity, Immunologic factors

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Antenatal noninvasive treatment of patients at risk for alloimmune thrombocytopenia without a history of intracranial hemorrhage

Article Abstract:

A noninvasive management of alloimmune thrombocytopenia is evaluated in which treatment includes only the blind administration of immunoglobulin in patients without a history of intracranial hemorrhage in a previously affected infant. The management procedure is highly effective and appears to be safe for women without a history of fetal/neonatal intracranial hemorrhage.

United States, Health aspects, Diagnosis, Pregnant women

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