The role of endothelium-derived hyperpolarizing factor in the regulation of the uterine circulation in pregnant rats

Article Abstract:

The physiological effects of endothelium-derived hyperpolarizing factor (EDHF) on uterine circulation in the rat is described. EDHF is released by endothelial cells but is not related to nitric oxide.

Endothelium, Uterine circulation

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Adaptation to pregnancy leads to attenuated rat uterine artery smooth muscle sensitivity to oxytocin

Article Abstract:

The study is conducted to test the hypothesis that oxytocin (OT) contracts blood vessels via vasopressin V1A (VP) receptors, and that this depends on pregnancy. It is concluded that OT and VP contract uterine arteries (UA) via their own receptors, adaptation to pregnancy led to attenuated sensitivity of UA smooth muscle to OT and transformed OT receptors into VP-like ones.

United States, Science & research, Health aspects, Pregnant women, Uterus, Uterine contractions, Oxytocin

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In vivo effects of corticotropin-releasing factor in pregnant rats

Article Abstract:

Corticotropin-releasing factor appears to lower blood pressure during pregnancy. This hormone is known to relax blood vessels. Researchers measured blood pressure in pregnant rats after an intravenous infusion of corticotropin-releasing factor and also measured the effect of corticotropin-releasing factor on strips of tissue taken from the uterine artery. Corticotropin-releasing factor lowered the rats' blood pressure and also relaxed the uterine artery samples. However, it did not affect the initiation of labor.

Blood vessels, Blood pressure, Corticotropin releasing hormone, Corticotropin-releasing hormone

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