The management of gout

Article Abstract:

The treatment of gout includes medication and an attempt at reversing contributing factors. Gout results from the deposit of urate crystals in joints or cartilage, causing inflammation and episodes of arthritis. Drugs for gout consist of colchicine, nonsteroidal antiinflammatory drugs, and corticosteroids. Colchicine causes diarrhea and abdominal pain, unless intravenously administered. Side effects limit the use of otherwise effective antiinflammatory drugs. Corticosteroid injections into the affected joint have been a very successful alternative to the other two types of medications. The production of urate can be prevented by a low-purine diet, weight control, and low alcohol consumption. Limiting the intake of foods high in purines may correct excessive amounts of uric acid in the blood. Organ meats, yeast, legumes, oatmeal, and asparagus contain high levels of purine.

Drug therapy, Obesity, Corticosteroids, Adrenocortical hormones, Hyperuricemia, Colchicine

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The severe gout of Holy Roman Emperor Charles V

Article Abstract:

The findings of massive gouty tophi with demonstrable urate deposits that confirm the clinical suspicion of severe gout in the unique sample from the mummified remains of the Holy Roman Emperor Charles V are reported. The evidence has confirmed that Charles V had severe gout, which was probably a determining factor in his decision to abdicate, and has illustrated how paleopathological studies can provide important information leading to an increased understanding of history.

Charles V, Holy Roman Emperor

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Gout

Article Abstract:

The prevention and treatment of gout are reviewed based on the case of a 59-year-old man. Gout is a form of arthritis that is caused by deposits of uric acid crystals in joints. Humans cannot metabolize uric acid, so excess amounts in the blood will form crystals. Men are seven to nine times more likely to develop gout than women.

Prevention

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