The many faces of rickets

Article Abstract:

Studies of the genetic mutations related to vitamin D-resistant rickets contribute substantially to the understanding of metabolic bone diseases. Rickets causes weakness, bone deformities, reduced blood levels of calcium, and other defects that may simply result from vitamin D deficiency. However, researchers have discovered a genetic mutation which causes vitamin D-deficient rickets, a condition which does not respond to simple vitamin supplementation. The mutation causes the absence of a critical enzyme in vitamin D metabolism, leading to the defect in bone development.

Editorial, Causes of, Genetic aspects, Bone diseases, Vitamin D, Vitamin metabolism, Rickets, Vitamin D metabolism

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Intensive insulin therapy in the medical ICU

Article Abstract:

A randomized and controlled study was performed on adult patients who were admitted in ICU for at least three days and randomly assigned to strict normalization of blood glucose level with the use of insulin infusion or to conventional therapy. The results revealed that the intensive insulin therapy reduced morbidity but not morality of patients in ICU and although the risk of deaths and disease was reduced in patients they could not be easily identified before the therapy.

United States, Management dynamics, Management, Usage, Company business management, Intensive care units

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Intensive insulin therapy in critically ill patients

Article Abstract:

Insulin therapy can lower mortality rates among critically ill patients even if they are not diabetic. In a study of 1,548 patients, insulin therapy not only lowered mortality rates but decreased the risk of kidney failure, bloodstream infection, and peripheral nerve disease and reduced the need for blood transfusions.

Care and treatment, Critically ill

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