The mutation frequency of feline immunodeficiency virus enhanced by 3'-azido-3'-deoxythymidine

Article Abstract:

The drug AZT may increase the mutation rate of HIV. AZT is the most commonly used drug in the treatment of HIV infection and AIDS. Researchers used a culture of kidney cells from cats to measure the effect of AZT and two other AIDS drugs on the mutation rate of feline immunodeficiency virus (FIV). FIV is related to HIV and causes an immune deficiency in cats. The feline kidney cell culture was exposed to a known mutagen, 5-bromo-2'-deoxyuridine (BUdR), to determine a baseline range of mutated viruses. Then similar cultures were exposed to AZT, ddI or ddC. AZT increased the mutation rate of FIV in a manner similar to BUdR. ddI and ddC did not cause a detectable increase in the mutation rate of FIV.

Zidovudine, Feline immunodeficiency virus

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Epstein-Barr virus DNA in the blood of infants, young children, and adults by age and HIV status

Article Abstract:

High levels of Epstein-Barr virus (EBV) DNA in the blood of children infected with HIV may be associated with lower concentrations of HIV in the blood. Researchers studied mononuclear white blood cells in children infected with HIV before birth and their HIV-infected mothers. Children infected with both viruses typically had EBV DNA levels hundreds of times higher than the women who were coinfected. EBV may have proliferated in the children after maternally acquired immunity declined. High levels of EBV DNA in children were associated with lower HIV viral load.

Physiological aspects, HIV infection in children, Pediatric HIV infections, Viruses, Epstein-Barr virus diseases

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The Kin-cohort study for estimating penetrance

Article Abstract:

A cross-sectional study is probably more suitable than a cohort or case-control study for studying the effect of a rare mutation in a cancer gene. The kin-cohort method uses volunteer infected subjects who have a higher risk of mutation. Researchers can infer the penetration of the mutation by averaging the risk in carriers and non-carriers and weight calculation.

Evaluation, Cohort analysis, Genetic research

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