The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor

Article Abstract:

Research presented concerns the impact of catecholamine neurotransmitter dopamine on angiogenesis, focusing on the anti-tumor effect of dopamine. Findings suggest that dopamine works with D(sub)2 dopamine receptors, inducing vascular endothelial growth factor receptor 2 endocytosis, which is key to promoting angiogenesis, while also preventing the binding of vascular permeability factor/vascular endothelial growth factor, receptor phoshorylation, and the following signaling effects.

Research

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The neurotransmitter dopamine inhibits angiogenesis induced by vasuclar permeability factor/vascular endothelial growth factor

Article Abstract:

Research suggests that the administration of dopamine at non-toxic levels inhibits angiogenesis induced by the malignant tumor-related cytokine vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). Topics include the effect of dopamine on the movement and proliferation of human umbilical vein endothelial cells and how dopamine reduces VEGF receptor 2 binding and phosphorylation.

Cytokines

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A novel function for tissue inhibitor of metalloproteinases-3 (TMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

Article Abstract:

The mechanism of inhibition of the vascular endothelial factor mediated angiogenesis by the tissue inhibitor of metalloproteinases-3 occurs by the enzyme's blocking the binding of the growth factor to its receptor thereby arresting downstream signaling.

United Kingdom, Sweden, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Enzyme Inhibitors, Protein binding

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