The primary immunodeficiencies

Article Abstract:

There are several immunodeficiency disorders. X-linked agammaglobulinemia and hyper-IgM syndrome result in pus-producing infections of the ears, eyes, sinuses, and lungs. The standard treatment for both diseases is intravenous immune globulin. Common variable immunodeficiency is caused by production of defective antibodies, resulting in frequent pus-producing infections of the respiratory tract. Patients with this disease often have gastrointestinal and lymph disorders. Severe combined immunodeficiency occurs in infants, causing viral infection, rash, diarrhea, and coughing. This immunodeficiency causes death if it is not treated immediately with a bone marrow transplant. Defects in the expression of the major histocompatibility complex class II causes gastrointestinal problems and respiratory infections. This disorder may be treated with bacille Calmette-Guerin or bone marrow transplant. Wiskott-Aldrich syndrome involves a depletion of T cells and may result in eczema, and various infections. This disorder is treated with removal of the spleen or immune globulin injections.

Immunological deficiency syndromes, Immunologic deficiency syndromes

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Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate

Article Abstract:

Vapor-heated C1 inhibitor concentrate appears to be effective in the treatment of hereditary angioedema. Hereditary angioedema is characterized by swelling of the extremities, face and larynx due to a C1 inhibitor deficiency. An infusion of vapor-heated C1 inhibitor concentrate significantly lowered swelling in 11 patients who were having an acute attack compared to 11 similar patients who received a placebo. The drug was well tolerated. Vapor heating eliminates blood-borne pathogens such as HIV.

Health aspects, Evaluation, Drug therapy, Enzyme inhibitors, Angioneurotic edema, Blood proteins, Complement deficiency (Immunology), Complement deficiencies

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Isolation of poliovirus-John Enders and the Nobel Prize

Article Abstract:

The most gracious in the history of the Nobel Prize, reveals the profound decency and modesty of John Enders. The study reveals the sensational finding that they had successfully propagated poliovirus in tissue cultures of cells of nonneurogenic origin.

United States, Achievements and awards, Poliovirus, Polioviruses, Enders, John Franklin

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