Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration

Article Abstract:

Study was conducted to describe that trans-arachidonic acids are major product of NO2(super .)-mediated isomerization of arachidonic acid within the cell membrane, but their biological relevance is unknown. The findings provide new insight into the molecular mechanisms of nitrative stress in retinal microvascular injury and suggest new therapeutic avenues in the management of disorders involving nitrative stress like retinopathies and encephalopathies.

Health aspects, Arachidonic acid, Diabetic retinopathy, Ischemia

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Antibody diversity: One enzyme to rule them all

Article Abstract:

The discovery of activation-induced cytidine deaminase (AID) has led to the elucidation of unified molecular mechanism for initiation of the last two reactions. The reason behind the B cells undergoing these reactions is prone to cancer-associated DNA damage.

B cells, Antibody diversity

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