Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury

Article Abstract:

A study is conducted to investigate regeneration and remodeling of central axons after injury by characterizing trans genic mice in which corticospinal tract (CST) fibers are specifically and completely labeled by yellow fluorescent protein (YFP). By using the CST-YFP mice, it is shown that minor CST components are responsible for most monosynaptic contacts onto motoneurons.

Care and treatment, Axons, Genetically modified mice

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In vivo imaging of axonal degeneration and regeneration in the injured spinal cord

Article Abstract:

The individual fluorescent axons in the spinal cords of living transgenic mice are monitored over several days after spinal injury. The results suggest that time-lapse imaging of spinal cord injury provides a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration.

Prognosis

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Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Article Abstract:

The contribution of the neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) to axonal degeneration in inflammatory lesions of the central nervous system (CNS) is examined. Results show that ASIC1 blockers can be used for providing neuroprotection in multiple sclerosis.

Central nervous system, Multiple sclerosis, Encephalomyelitis

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