Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP-0127): results of a randomized, double-blind, placebo-controlled trial

Article Abstract:

Deltibant appears to be ineffective in treating septic shock although it may help patients infected with gram-negative bacteria. Septic shock is a widespread inflammatory response to bacterial infection that results in organ failure and death. Researchers randomly gave the drug deltibant or a placebo to 504 patients in septic shock and followed their progress for 28 days or until death. The drug made no difference in survival rates but those infected with gram-negative bacteria showed some improvement. Deltibant blocks the production of bradykinin, which has been implicated in septic shock.

Drug therapy, Septic shock

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Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial

Article Abstract:

The clinical efficacy of low-dose (5-ppm) inhaled nitric oxide in patients with acute lung injury is evaluated. Inhaled nitric oxide at a dose of 5 ppm in patients with acute lung injury not due to sepsis and without evidence of nonpulumonary organ system dysfunction results in short-term oxygenation improvements, but has no substantial impact on the duration of ventilatory support or mortality.

Nitrogen Oxide Gases, Care and treatment, Lung diseases, Nitrogen oxides, Nitrogen oxide

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Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide

Article Abstract:

A study to observe the effects of less intake of cocoa on blood pressure is presented. Results conclude that inclusion of small amounts of cocoa efficiently reduces BP and improved the formation of bioactive nitric oxide.

Chocolate and Confectionery Manufacturing from Cacao Beans, Chocolate and cocoa products, Powdered Cocoa, Blood pressure, Cocoa, Clinical report

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