VX-680, a potent and selective small-molecule inhibitor of the Aurora-kinases, suppresses tumor growth in vivo

Article Abstract:

The discovery of a highly potent and selective small-molecule inhibitor of Aurora kinases, VX-680 that is essential for the regulation of chromosome segregation and cytokinesis during mitosis is reported. Data indicates that Aurora kinase inhibitor provides a new approach for the treatment of multiple human malignancies.

Protease inhibitors

---

Tissue-print and print-phoresis as platform technologies for the molecular analysis of human surgical specimens: Mapping tumor invasion of the prostrate capsule

Article Abstract:

A set of novel 'tissue print' and 'print phoresis' technologies to facilitate tissue and tumor-marker profiling under these circumstances are developed. These technologies are used to identify and characterize markers of tumor invasion of the prostrate capsule that may result in tumor at the surgical margins.

Cancer, Tumor markers, Tumour markers

---

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six - 1 as key metastatic regulators

Article Abstract:

Ezrin, a cytoskeletal organizer and Six - 1, a developmental homeoprotein are identified as regulators of metastasis in rhabdomyosarcoma (RMS). They further provide new mechanistic and therapeutic insights for the pediatric cancer.

Genetic aspects, Metastasis, Cancer metastasis, Rhabdomyosarcoma

Similar abstracts:

• Abstracts: Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Savior and slayer: The two face of p53
• Abstracts: Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Calcium handler mishandles heart

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.