Vasoactive effects of neurokinin B on human blood vessels

Article Abstract:

Neurokinin B is probably not involved in causing a serious complication of pregnancy called preeclampsia, according to researchers who exposed blood vessels from biopsy specimens to this substance. Neurokinin B is produced by the placenta and it is clear that an abnormal placenta causes preeclampsia. But this study of 26 women and 4 rats shows that neurokinin B may not be involved.

Physiological aspects, Blood vessels

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The involvement of rho-associated kinases in agonist-dependent contractions of human maternal and placental arteries at term gestation

Article Abstract:

A study is conducted to assess the involvement of rho-associated kinase (ROK) in agonist-dependent contraction of omental, myometrial and placental arteries of pregnant women at term. Results of the study form the first report of the involvement of ROK in the receptor-coupled constriction of intact and permeabilized arteries from pregnant women.

United States, Cells, Cell permeability, Pregnancy, Complications of, Pregnancy complications, Agonists (Biochemistry)

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Effects of a phosphodiesterase-5 (PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries

Article Abstract:

A study is conducted to determine that phosphodiesterase-5 (PDE5) inhibition could improve endothelium-dependent function in preeclampsia. The conclusion states that a PDE5 inhibitor enhances endothelial function of myometrial vessels from women with preeclampsia, such that the behavior of these arteries approximates to those from normal women.

Myometrium, Phosphodiesterases

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