A physiological role for PAF in the stimulation of mammalian embryonic development

Article Abstract:

The platelet-activating factor (PAF) formed by both mouse and human preimplantation embryos was found to function as an autocrine growth factor that affected the development of embryos during pregnancy. The PAF represented a group of growth factors, which enhanced pregnancy potentials, obtained from the embryo during its first stages of development. Moreover, the physiological activity of PAF included inflammation and allergy control. The role of PAF as fertility enhancing agents could be hinderd with the introduction of PAF inhibitors or antagonists.

Physiological aspects, Embryology, Animal embryology, Autocrine mechanisms, Platelet activating factor

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Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family

Article Abstract:

Secretin receptors and frizzled proteins share a structural similarity and putative evolutionary homology. Results of a study showed that they share a cysteine-rich extracellular amino terminus that may support a role in ligand recognition. Moreover, findings of sequence alignments indicated that the proteins support a novel G protein-coupled receptor family. It is also suggested that adenylate cyclase-based signalling may also be supported in the frizzled receptor family.

Analysis, Proteins, G proteins, Ligands, Ligands (Chemistry)

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