Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine

Article Abstract:

The results from the neurogenic inflammation and c-fos expression studies have confirmed the neural transmission blockade mechanism of both sumatriptan and ergot alkaloids in relieving vascular headaches. The mitigating mechanism involves the mediation of a prejunctional 5-hydroxytryptamine-like receptor which constricts coronary artery and intra-cranial vascular smooth muscle. Furthermore, the neuronal mechanism of sumatriptan and ergot alkaloids makes them viable medications for migraines complicating meningeal inflammation.

Drugs, Physiological aspects, Meningitis, Sumatriptan, Structure-activity relationships (Pharmacology), Ergot alkaloids, Migraine

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5-HT1-like receptors: six down and still counting

Article Abstract:

Pharmacological studies reveal that the application of molecular cloning techniques yielded a diverse set of neurotransmitter receptors which exhibit the capacity for exploitation in the area of selective drug development. These findings are best illustrated by the cloning of 5-HT (serotonin) receptors. Other studies validate these results but indicate biphasic curve solutions to displacement studies.

Research, Cloning, Neurotransmitter receptors

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