Anthranoid laxatives and colorectal cancer

Article Abstract:

Several anthranoid laxatives extracted from herbal sources such as rhubarb, senna and aloe have been found to feature genotoxic properties which may lead to colorectal cancer. The genotoxicity of the anthranoids in rodents causes frame-shift mutations which indicate the significance of the dihydroxyanthraquinone structure in the carcinogenic activity. Studies involving chronic anthranoid laxative abuse in humans correlates with the apparent genotoxic potential of anthranoids. These results suggest a higher colorectal cancer risk can be observed with the use of anthranoid laxatives.

Physiological aspects, Colorectal cancer, Carcinogens, Laxatives, Anthraquinones

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Sequential theories for stomach cancer

Article Abstract:

Stomach cancer investigations have provided different theories for the prevalence of the disorder in some people, but not a single theory substantiates its occurrence. Food intake, genetic background, lifestyle and environment are examined to understand effects on stomach cancer. The continuous replacement of theories regarding incidence of stomach cancer further diversifies the range of factors that underlie the disorder. Even the latest theory involving Helicobacter pylori invasion of the gastric mucosa is as reliable as the theory it has displaced.

Analysis, Nutritionally induced diseases, Nutrition disorders, Helicobacter pylori, Stomach cancer

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Nucleoside diphosphate kinases as potential new targets for control of development and cancer

Article Abstract:

Studies have classified gene nm23 and the awd gene from Drosophila as nucleoside diphosphate kinases, a group of enzymes which play a role in cellular regulation and metastatic control of tumors. Gene nm23, which has been proven to be responsible for mammalian tumor malignancy, was discovered through the differential screening of the cDNA. It is often correlated with high metastatic potential.

Genetic aspects, Cancer, Cancer genetics, Metastasis, Cancer metastasis, Nucleosides

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