Cysteine sulphinic acid as a candidate endogenous EAA ligand

Article Abstract:

The sulphur amino acids, homocysteine sulphinic acid (HCSA), homocysteic acid (HCA), cysteine sulphinic acid (CSA) and cysteic acid, have been found to exhibit neuroexcitatory activities in the body. Physiological evidences support the ability of HCSA, HCA and CSA to serve as neurochemical agents. This discovery expands the metabolic roles of these compounds as intermediates in hypotaurine and taurine biosynthesis. In addition, further experiments show that CSA can be considered as an endogenous amino acid.

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Uniform distribution of CSA undermines neurotransmitter role

Article Abstract:

L-cysteine sulphinic acid (CSA) featured neuroexcitatory properties that were comparable to the glutamate analogue, L-homocysteic acid. This indicated the possible role of CSA as a potent neurotransmitter. However, conducted studies failed to confirm the neurotransmitter function of CSA. The apparent uniform distribution of CSA in the neuronal tissues was not sufficient to support its physiological excitatory action.

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Release of soluble nucleotidases: a novel mechanism for neurotransmitter inactivation?

Article Abstract:

Soluble nucleotidases are released from nerves. Research has shown that when the sympathetic nerves innervating the vas deferens of guinea pigs are stimulated, neuronal adenosine 5'-triphosphate (ATP) and soluble nucleotidases are released. The soluble nucleotidases break down ATP to adenosine. This release of specific nucleotidases may be another mechanism for terminating the actions of neurotransmitters.

Research, Neurotransmitters, Nucleotidases

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