Glutamate receptors and asthmatic airway disease

Article Abstract:

Much progress has been made in understanding the pathophysiology of central glutamate receptors. Significant advances have also been made in clarifying the importance of these glutamate receptors in neuronal plasticity and in several neurological disorders. New insights into glutamate receptor function have also been formed from the examination of the role of these receptors in peripheral tissues such as the lungs and airways. It is now known that their overactivation leads to the mimicking of asthmatic responses, a finding that suggests new approaches for asthma treatment.

Care and treatment, Physiological aspects, Asthma, Lungs, Lung, Glutamate, Cell receptors, Respiratory system, Neurotransmitters, Respiratory organs

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Subunit structure of native GABAA receptors in the mammalian CNS

Article Abstract:

The analysis of amino acid sequences from the mammalian central nervous system using molecular cloning with the gamma-aminobutyric acid (sub A) (GABA) suggest that GABA (sub A) receptors contain amino acids with hydrophobic regions, an arrangement that is similar to the organization of nicotinic acetylcholine receptors. Thus, it is assumed that the GABA (sub A) is also capable of pseudo-pentameric symmetry.

Central nervous system, Nicotinic receptors, GABA, GABA receptors

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